비페닐디메칠디카르복실레이트 주사제의 설계 및 평가

• 영문명: Design and Evaluation of Biphenyl Dimethyl Dicarboxylate Injections
• 발행기관: 대한약학회
• 저자명: 김혜진(Hye Jin Kim) 전인구(In Koo Chun)
• 간행물 정보: 『약학회지』제44권 제3호 (2000년), 263~271쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.06.29

영문 초록

In an attempt to develop an injectable form of practically insoluble biphenyl dimethyl dicarboxylate (DDB), the effect of various vehicles, cosolvents and hydrotropic agents was investigated. It was found that polyethylene glycol (PEG) 400 revealed the best solvency toward DDB (17.7mg/ml at 370C), and decreasing order of the solubility was as follows: PEG 400 > PEG 300 > diethylene glycol monoethyl ether (DGME) > PEG-8 glyceryl caprylate/caprate. Among the hydrotropes used, sodium salicylate, sodium benzoate and nicotinamide were effective in increasing the solubility in water. The solubility of DDB in 2M sodium salicylate, sodium benzoate and cotinamide solutions was increased 44.3, 23.5 and 44.0 times than that in water, respectively. The addition of sodium salicylate and sodium benzoate to PEG 300-water, PEG 400-water and DGME-water cosolvents remarkably increased the solubility of DDB, and significantly retarded precipitate formation when mixed with water. Hemolytic properties of DDB injections (2mg/4~10ml) in PEG 300-water or DGME-water (60:40 v/v) cosolvents containing sodium benzoate (0.14~0.35M) were very low. It was concluded from the results that these solutions would be applied to the design of new DDB injections.

키워드

Biphenyl dimethyl dicarboxylate Injections Hydrotropic solubilization Hydrotropes Hemolysis.