입체구조적으로 안정화된 리포좀의 특성 및 혈장내 안정성

• 영문명: Characterization of Sterically Stabilized Liposomes and Their Stability in Rat Plasma in Vitro
• 발행기관: 대한약학회
• 저자명: 이지혜(Ji Hye Lee) 이상길(Sang Kil Lee) 전호성(Ho Seong Jeon) 김하형(Ha Hyung Kim) 이도익(Do Ik Lee) 이민원(Min Won Lee) 최영욱(Young Wook Choi)
• 간행물 정보: 『약학회지』제44권 제3호 (2000년), 251~256쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.06.29

영문 초록

Sterically stabilized liposomes (SSL) composed of distearoylphosphatidylcholine, cholesterol, dicetylphosphate and distearoylphosphatidylethanolamine-N-poly (ethyleneglycol) 2000 (DSPE-PEG 2000) were made by reverse phase evaporation method to prolong biological half-life and decrease toxic side effect of drug. Streptozocin (STZ), a water-soluble antitumor agent with short half-life, was selected as a model drug. The size of SSL was controlled by polycarbonate extrusion to 100nm which is adequate size for long circulation in plasma. The release rate of drugs from SSL in PBS was evaluated. And the stability of STZ-containing liposomes against drug leakage into rat plasma was evaluated in order to investigate the interaction of liposome and plasma protein. Incorporation of DSPE-PEG 2000 into conventional liposomes significantly decreased the drug leakage into rat plasma.

키워드

Sterically Stabilized Liposome Drug Release Stability DSPE-PEG 2000 Streptozocin.