과체 성분의 간질환 모델에서의 효과

• 영문명: Effects of the Constituents of Melonis Pedicellus in the Animal Models of Hepatic Diseases
• 발행기관: 대한약학회
• 저자명: 최선희(Seon Hee Choi) 이석용(Seok Yong Lee) 조태순(Tai Soon Cho)
• 간행물 정보: 『약학회지』제44권 제1호 (2000년), 87~94쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.02.28

영문 초록

In order to investigate the hepatoprotective constituents, Melonis Pedicellus was systematically extracted and fractionated with n-hexane, ethyl acetate, butanol and Water. Treatment of rats with ethyl acetate fraction reduced hepatic injuries induced by alpha-naphthylisothiocyanate or D-galactosamine, whereas the components in water fraction showed protective effect only against D-galactosamine-induced hepatitis in rats. Two cucurbitacins and three sterols were isolated from ethylacetate fraction and their chemical structures were identified as cucurbitacin B, isocucurbitacin B, alpha-spinasterol, stigmast-7-en-3-ol and stigmast-7-en-3-ol-0-beta-D-glucopyranoside. Cucurbitacin B at the dose of 1mg/kg (p.o.) significantly increased in bile flow in rats with ANIT-induced cholestasis. Isocucurbitacin B at 5mg/kg (p.o.) showed significant protective effects against ANIT-induced cholestasis. These results showed that cucurbitacin B and isocucurbitacin B from Melonis Pedicellus may have hepatoprotective effect in rats with experimental cholestasis.

키워드

Melonis Pedicellus Cucumis melo hepatoprotective constituents