SKF 525A가 흰쥐의 대동맥에서 Sodium nitroprusside, Acetylcholine, Pinacidil에 의한 이완반응에 미치는 효과

• 영문명: The effect of SKF 525A on SNP-, Ach-, or Pinacidil-Induced Relaxation in the Aorta of Rat
• 발행기관: 대한약학회
• 저자명: 박조영(Jo Young Park) 김학림(Hak Lim Kim) 김주원(Ju Won Kim) 신창열(Chang Yell Shin) 최윤미(Yoon Mee Choi) 김진학(Jin Hak Kim) 안형수(Hyung Soo Ahn) 손의동(Uy Dong Sohn) 허인회(In Hoi Huh)
• 간행물 정보: 『약학회지』제44권 제1호 (2000년), 80~86쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.02.28

영문 초록

TEA, glibenclamide, L-NAME and SKF 525A-induced contraction were investigated using acetylcholine, sodium nitroprusside (SNP, NO donor) and pinacidil (ATP sensitive K+ channel opener) in rat abdominal and thoracic aorta. The relaxant effects of acetylcholine, SNP and pinacidil were not different in the abdominal aorta and in the thoracic aorta. Acetylcholine-induced relaxation was dependent on endothelial cell, but pinacidil was independent endothelia cell. In the presence of TEA, glibenclamide, L-NAME,mepacrine and SKF 525A, acetylcholine and SNP did not change, but pinacidil-induced relaxation was significantly reduced in presence of glibenclamide, which is ATP sensitive K+ channel blocker. SKF 525A, which is inhibitor of cytochrome P450 dependent epoxygenase, partially inhibited the pinacidil-induced relaxation. These results indicate that the pinacidil-induced relaxation may be mediated by ATP sensitive K+ channel and partially by EETS, which is produced by cytochrome P450 dependent epoxygenase.

키워드

SKF 525A TEA SNP pinacidil glibenclamide L-NAME mepacrine EETs