Propranolol.HCl의 Cellulose Acetate Phthalate Microencapsulation에 관한 연구

• 영문명: Microencapsulation of Propranolol.HCl with Cellulose Acetate Phthalate
• 발행기관: 대한약학회
• 저자명: 구영순(Young Soon Ku) 김재연(Jae Youn Kim)
• 간행물 정보: 『약학회지』제33권 제5호 (1989년), 312~318쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.10.28

영문 초록

Microcapsule of Propranolol.HCl with Cellulose Acetate Phthalate(CAP) by coacervation-phase separation method was studied. Encapsulation was carried out in the CAP-liquid paraffin-acetone ethanol solvent system. The optimum weight ratio for microencapsulation in the CAP-liquid paraffin-solvent system was 1.32:89.18:9.50 or 1.65:89.42:8.93. The wall thickness of microcapsules increased according to increasing of CAP concentration, but dissolution rate decreased. The dissolution of propranolol-HCl in simulated gastric and intestinal fluid test solution was completed within 3 min., but T50% of propranolol.HCl from 10.0% CAP-microcapsules were 390 min. and 210 min. respectively. The released amount from 12.5% CAP-microcapsules,was 41.8% within 720 min. in simulated gastric fluid test solution and T50% of those in simulated intestinal fluid test solution was 250 min.