약물-고분자물질 결합체 합성연구 : 5-fluorouracil과 사람의 혈청 Albumin 및 Poly-L-lysine 결합체 합성

• 영문명: Synthesis of Drug-macromolecule Conjugates: Conjugations of 5-Fluorouracil to Human Serum Albumin and Poly-L-lysine
• 발행기관: 대한약학회
• 저자명: 이희주(Hee Joo Lee) 신혜순(Hae Soon Shin) 이명길(Myung Gull Lee) 박만기(Man Ki Park) 김종국(Chong Kook Kim)
• 간행물 정보: 『약학회지』제33권 제5호 (1989년), 267~272쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.10.28

영문 초록

The drug-macromolecule conjugates i.e. 5-fluorouracil-1-acetyl-human serum albumin(FU-AA-HSA, 8) and 5-fluorouracil-1-acetyl-poly-L-lysine(FU-AA-polylys, 9) have been synthesized and purified by sephadex G-25 gel filtration with 0.05M phosphate buffer(pH 7.5). The analyses of conjugates gave the molar ratio of FU-AA : HSA of 70-100:1 and FU-AA: poly-L-lysine of 109:1. The weight percent of FU-AA(as FU-CH2CO-) in FU-AA-HSA conjugate was 16-22% and the one in FU-AA-polylys was 22.4%.

키워드

5-Fluorouracil 5-fluorouracil-1-acetic acid human serum albumin poly-L-lysine drug-macromolecule conjugate.