마우스에 있어서 에이코사펜타엔산이 면역반응에 미치는 영향(I) I. 체액성 면역

• 영문명: The Effect of Eicosapentaenoic Acid on the Immune Response in Mice(I) I. Humoral-mediated immunity
• 발행기관: 대한약학회
• 저자명: 안영근(Young Keun Ahn) 김정훈(Joung Hoon Kim) 이상근(Sang Keun Lee) 김행순(Haeng Soon Kim)
• 간행물 정보: 『약학회지』제33권 제1호 (1989년), 20~29쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.02.25

영문 초록

The humoral immune response of Eicosapentanoic acid(EPA) was investigated in mice. ICR male mice were divided into 8 groups and received intraperitoneal injection of EPA(5mg, 10mg, 20mg/kg) for 4 weeks. Cyclophosphamide(5mg/kg) was administered i.p. 2 days prior to secondary immunization. Humoral immune response was evaluated by antibody titer, hypersensitivity to SRBC(Arthus), plaque forming cell(PFC) and organ weight. The obtained results were as followings: The increased rate of body weight, the ratio of liver weight, spleen weight to body weight were decreased by all EPA administration groups as compared to normal group. HA titer, HY titer and Arthus reaction were enhanced according to the increase of EPA doses as compared to normal group. PFC was significantly enhanced by EPA 10mg administration group. These results suggest that EPA enhances humoral immune response to SRBC in mice, indicating that EPA may block a immunoglobulin synthesis inhibition of arachidonic acid.