인삼 Saponin, 은시호 Saponin 및 계면활성제가 적혈구의 용적변화 및 Fragility에 미치는 영향

• 영문명: Effect of Ginseng Saponin, Gypsophila Saponin, and Detergents on Volume Changes and Fragility of Red Blood Cells
• 발행기관: 대한약학회
• 저자명: 이신웅(Shin Woong Lee) 이정수(Jeung Soo Lee) 이수근(Soo Kun Lee) 옥창건(Chang Kun Ok) 김영희(Young Hie Kim)
• 간행물 정보: 『약학회지』제33권 제1호 (1989년), 15~19쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.02.25

영문 초록

The effects of Gypsophila saponin, sodium dodecylsulfate (SDS) and Triton X-100 on volume changes and fragility of red blood cells were compared to ginseng saponin to elucidate whether there are any difference in their action on membrane lipid. Cell volume was decreased to about 38% in 1M NaCl and increased to about 20% in 1/10M NaCl. Hematocrit value was decreased by Gypsophila saponin, SDS, and Triton X-100 which caused hemolysis in isotonic NaCl solution. These detergents also inhibited increase of cell volume and accelerated hemolysis in hypotonic solution. However, ginseng saponin did not influence to osmotic volume changes and hemolysis of red blood cells. These results suggest that the disruptive effect of plant saponin on membrane barriers induced by removing membrane lipid is different from their source and ginseng saponin has very low affinity to membrane lipid.