강활 에틸아세테이트 분획에 의한 PG 분해 iNOS, PGE2, 활성 억제 및 진통효과

• 영문명: Analgesic Activity and Inhibitory Effect of PG Degradation, iNOS and PGE2 by Ethyl Acetate Fraction of Angelica Koreana Radix
• 발행기관: 대한약학회
• 저자명: 김시나(Si Na Kim) 이현지(Hyun Ji Lee) 이은정(Eun Jeong Lee) 남경숙(Gyeong Sug Nam) 김희석(Hee Seok Kim) 황성완(Sung Wan Hwang) 황성연(Sung Yeoun Hwang)
• 간행물 정보: 『약학회지』제50권 제2호 (2006년), 99~104쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Prostaglasdins biosynthesis and nitric oxide production have been implicated in the process of inflammation In this study, we investigated on the effects of ethyl acetate extract of Angelica Koreana Radix (EAKR) on the activities of prostaglandin E2 (PGE2), proteoglycan (PG) degradation and nitric oxide synthase (NO) in inflammation cytokines-activated rabbit articular chondrocytes. EAKR exhibited inhibitory activities on NO production and PGE2 production as 73.08% and 89.49%, respectively at 20 ㎍/㎖ and inhibited the degradation of PG in a concentration-dependent manner. Zelatin zymog- raphy analysis demonstrated that EAKR significantly inhibited MMR-2, 9 expression in chondrocytes. In vivo, EAKR was shown to have inhibitory effects on acetic acid-induced pain. This study suggests that modulation of PGE2, NO, PG degradation and MMP-2, 9 by EARK may be important in the prenebtion of inflammation and osteroarthritis.

키워드

anti-inflammation PGE2 MMPs Angelica Koreana Radix osteoarthritis