한국 성인에서 분리한 유산균의 VISA (Vancomycin-Intermediate Resistant Staphylococcus aureus)와 VRE (Vancomycin Resistant Enterococcus faecium)에 대한 성장 억제

• 영문명: Lactic Acid Bacteria Isolated from Healthy Korean Having Antimicrobial Activity Against VISA and VRE
• 발행기관: 대한약학회
• 저자명: 윤지희(Ji Hee Yun) 김윤아(Yun A Kim) 송문석(Moon Seok Song) 강병용(Byung Yong Kang) 하남주(Nam Joo Ha)
• 간행물 정보: 『약학회지』제50권 제2호 (2006년), 78~83쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Visa and VRE are the main causes of surginal infection, urinary tract infections and bacteremia in hospitals. In this study, we selected VISA (Vancolycin Intermediate resistant Staphylococcus aureus) and VRE (Vancomycin Resistant Enterococcus) isolated from the clinical isolates, One of the isolated strains indicated the high resistance to several anti-biotics (Vancomycin, Teicoplanin, Mupirocin, Synercid, Ciprofloxacin, Lincomycin, Cefotaxim, Meropenem). Antimicribial activity of Bifidobacterium spp. against VISA and VRE were measured. About 104cells of VISA or VRE were mixed with 1,5 and 9 ㎖ of Bifidobacterium and the final volume was adjusted to 10㎖ with brain heart infusion (BHI) broth. The cell suspension was incubated for 3, 6, 9,and 24 hr, serially diluted and then plated on BHI agar plate. As numbers of Bifibobacterium were increased viable cell count of VISA and VRE decreased. The strongest antimicrobial activity of the Bifibobacterium was observed after 9hr incubation in any mixture, almost completely inhibiting the growth of VISA and VRE.

키워드

lactic acid bacteria VISA and VRE