석창포 헥산 추훌물이 Staphylococcus aureus SA2의 Chloramphenieol Acetyltransferase에 미치는 영향

• 영문명: Effect of Hexane Extract of Acori graminei Rhizoma on Chloramphenicol Acetyltransferaseof Staphylococcus aureus SA2
• 발행기관: 대한약학회
• 저자명: 문경호(Kyung Ho Moon) 권주열(Joo Yeoul Kwon) 박민수(Minsoo Park) 김혜경(Hyekyung Kim) 이정규(Chung Kyu Lee)
• 간행물 정보: 『약학회지』제48권 제1호 (2004년), 30~33쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.02.28

영문 초록

One subfraction from the hexane fraction of Acori graminei Rhizoma, the E4 fraction which is mainly consisted of acorenone, showed a potential inhibitory activity against chloramphenicol acetyltransferase (CAT) of S. aureus SA2 that is a multidrug-resistant strain to 10 usual antibiotics. The combination therapy of this fraction with chloramphenicol resulted in reduction of the minimal inhibitory concentration from 128 μg/ml to 8 μg/ml. The E4 fraction also revealed to prevent the induction of CAT from this strain.

키워드

chloramphenicol acetyltransferase Staphylococcus aureus SA2 growth inhibition antibiotics resistance resistance inhibition Acori graminei Rhizoma acorenone.