조각자 물추출물의 항염증 작용

• 영문명: Anti-inflammator Activity of Aqueous Extrat from Gleditsiae Spina
• 발행기관: 대한약학회
• 저자명: 박은희(Eun Hee Park) 신미자(Mee Ja Shin)
• 간행물 정보: 『약학회지』제37권 제2호 (1993년), 124~128쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.04.30

영문 초록

The anti-inflammatory activity of the aqueous extract from Gleditsiae spina was investigated utilizing carrageenin-induced edema, granuloma pouch and adjuvant arthritis in rats. The effects of this agent on vascular permeability and acetic acid-induced writhing in mice were also examined. Its anti-inflammatory activity on carrageenin edema was observed with oral administration. The aqueous extract from Gleditsiae spina(400mg/kg, 7 days) showed significant inhibitory effects on granuloma and exudate formation in rats. In the method of adjuvant arthritis, the aqueous extract(400mg/kg), orally administered for 21 days, inhibited the development of hind paw edema in rats. The aqueous extract was also inhibited the increase in vascular permeability and the number of writhings induced by acetic acid in mice. In the present study, the aqueous extract of Gleditsiae spina was indicated to have the anti-inflammatory action.

키워드

aqueous extract Gleditsiae spina phenylbutazone prednisolone anti-inflammatory activity.