테오필린과 페플록사신과의 상호작용

• 영문명: Interaction of Theophylline and Pefloxacin
• 발행기관: 대한약학회
• 저자명: 장일효(Il Hyo Chang) 최준식(Jun Shik Choi) 이진환(Jin Hwan Lee)
• 간행물 정보: 『약학회지』제36권 제4호 (1992년), 321~325쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.08.30

영문 초록

Pharmacokinetic interaction of theophylline with pefloxacin following iv. administrations was investigated in rabbits. Pefloxacin was coadministrated at doses of 10 and 20mg/kg or previously administered for 6 days 10 and 20mg/kg. Plasma concentration and AUC of theophylline were increased significantly (p<0.05) and the renal clearance (CLr), total body clearance (CLt) and the volume of distribution (Vdss) were decreased significantly (p<0.005) by the pretreatment. It demonstrates that adjustment of dosage regimen of theophylline should be considered when concomitant administration of pefloxacin is prescribed.