새로운 메탄올 자화세균에 의한 트레오닌의 생산

• 영문명: Threonine Production by A Newly Isolated and Characterized Methylotrophic Bacterium
• 발행기관: 대한약학회
• 저자명: 김경자(Kyoung Ja Kim) 박귀례(Kui Lea Park)
• 간행물 정보: 『약학회지』제36권 제4호 (1992년), 315~320쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.08.30

영문 초록

The amino acid threonine was produced from glycine and ethanol in a reaction mixture using resting cells of a newly isolated gram-negative methylotrophic bacterium, capable of growth on methanol. The isolate could utilize C1 compounds and a variety of multicarbon substrates as sole carbon and energy source. To obtain cells of isolate with high threonine producing activity, we investigated optimum cultural conditions. Optimal growth was at the initial concentration of 0.5%(v/v) methanol, at 30oC and pH 7.0. The growth was not affected by antibiotics inhibiting cell wall synthesis, but was completely suppressed by those inhibiting protein synthesis. The optimum reaction conditions from threonine production by resting cells of this strain were found.