Hydrochlorthiazide가 Carteolol의 약동력학에 미치는 영향

• 영문명: The Effects of Hydrochlorothiazide on the Pharmacokinetics of Carteolol in Rabbits
• 발행기관: 대한약학회
• 저자명: 정혜주(Hye Joo Jeong) 조윤성(Yun Sung Chough) 김낙두(Nak Doo Kim) 고광호(Kwang Ho Ko)
• 간행물 정보: 『약학회지』제27권 제2호 (1983년), 149~154쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.06.30

영문 초록

The effect of hydrochlorothiazide on the pharmacokinctics of carteolol in rabbits was studied. Animals were divided into two groups (group I and group II). Group I received carteolol (12mg/kg) and group II received carteolol (12mg/kg) with hydrochlorothiazide (20mg/kg) orally. The carteolol concentration in serum was measured by spectrofluorometric method and its pharmacokinetic parameter values were calculated. The serum concentration of carteolol in group II was significantly increased when compared with those in group I at 10 min (p<0.01), and at 30 min (p<0.05) after p.o. administration. In addition, the absorption rate constant of carteolol in group II was slightly increased and Tmax of carteolol in group II was significantly shortened (pCmax of carteolol in group II was significantly increased (p