흰쥐의 Thioacetamide에 의한 간장해에 미치는 Silymarin 과 염산 Promethazine의 약물 상호작용에 관한 연구

• 영문명: Studies on the Drug Interaction of Silymarin with Promethazine Hydrochloride in Thioacetamide Hepatotoxicity of Rats
• 발행기관: 대한약학회
• 저자명: 조윤희(Youn Hee Cho)
• 간행물 정보: 『약학회지』제23권 제1호 (1979년), 41~49쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1979.03.30

영문 초록

By intraperitoneal administration of thioacetamide to rats, acute liver injury was produced. In these rats, the level of serum GOT and GPT activities showed a remarkable increase and the principal histopathologic change was centrilobular hepatic necrosis. In this study, combined administration of silymarin with promethazine hydrochloride to the rats with acute liver injury which was produced by thioacetamide inhibited the increase of serum transaminase activities and protected the histopathologic change, showing comparatively more improved results than simple administration of silymarin alone. On the basis of these results, it is suggested that promethazine hydrochloride potentiates the effectiveness of silymarin in acute thioacetamide hepatotoxicity of rats.