Gas Liquid Chromatography에 의한 Dienestrol Cream 중의 Dienestrol 정량

• 영문명: Determination of Dienestrol in Dienestrol Cream by Gas Liquid Chromatography
• 발행기관: 대한약학회
• 저자명: 백남호(Nam Ho Paik) 박남기(Man Ki Park) 류경수(Kyung Soo Yu) 염정옥(Jeong Rok Youm)
• 간행물 정보: 『약학회지』제23권 제1호 (1979년), 7~10쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1979.03.30

영문 초록

A gas chromatographic determination of dienestrol in dienestrol cream has been studied. Dienestrol cream was dissolved in pyridine and silylation was done by using N, O-bis (trimethylsilyl) trifluoroacetamide. The derivative was injected into 3% silicone OV-17 column for chromatographic estimation. The dienestrol peak was found to be well separated from the other components of the cream. The detection limit was obtained to be 5.6 X 10-11mol of dienestrol for this method. As there is no need for prior separation procedure, this experiment is extremely simple and less time consuming as compared to the conventional methods for estimation of dienestrol in cream.