Nitrofuran계 의약품의 안전성에 관한 착물화학적 연구(I) Mo-thiol착물에 의한 Nitrofurazone의 촉매환원

• 영문명: Coordination Chemical Approach to the Safety of Nitrofuran Drugs I. Reduction of Nitrofurazone Catalyzed by Molybdothiol Complexes
• 발행기관: 대한약학회
• 저자명: 김종윤(Jong Yoon Kim) 최보길(Bo Gil Choi)
• 간행물 정보: 『약학회지』제21권 제4호 (1977년), 184~192쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1977.12.31

영문 초록

In the presence of dithionite, two kinds of molybdothiol complexes, particularly isolated Mo-cysteine complexes, used as models for xanthine oxidase or aldehyde oxidase exhibited catalytic activity on the reduction of nitrofurazone to its amino derivative. Of the two Mo-cysteine complexes, the activity of oxo-bridged one was apparently greater than that of sulfido-bridged one. The promoting effect was hardly shown by added cofactors or their replacements of the enzymes. The catalyzed reduction is considered to take place by consecutive direct two-electron transfer mechanism from catalytically active reduced form of the molybdothiol complexes to nitrofurazone and the probable intermediates.