카모마일 꽃 추출물의 Candida albicans 기인성 감염성 관절염에 대한 효과

• 영문명: Effect of Chamomile Flower Extract on Septic Arthritis due to Candida albicans
• 발행기관: 대한약학회
• 저자명: 김정현 김송이 홍유나 김영식 한용문
• 간행물 정보: 『약학회지』제58권 제5호 (2014년), 343~348쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.31

영문 초록

In the present studies, we examined effect of chamomile flowers extract (CH-Ex), which has traditionally been used as antiphlogistics in Europe for many centuries, against Candida albicans-caused septic arthritis. Candida albicans is a major etiological agent among fungal septic arthritis. This effect was investigated in a murine model of the septic arthritis. That is, mice that were given an emulsion form of C. albicans cell wall (CACW) via footpad route were treated intra-peritoneally with the CH-Ex for 3 times every 3 days. Degrees of the footpad-swellings were measured with dial gauger. Data showed that the CH-Ex resulted in the reduction of swelling. For instance, at Day 9 when swelling reached the highest peak, there was up to app. 60% reduction of edema in mice injected with the CH-Ex, compared to that of the control mice that received no treatment (P<0.05). This therapeutic anti-arthritic activity appeared to be mediated by inhibitions of NO (nitric oxide) production from activated RAW264.7 macrophages and proliferation of Con A-treated T lymphocytes. Analysis by HPLC revealed that the CH-Ex contained eight polyphenolic compounds including chlorogenic acid (CRA) and rutin. We have reported the CRA and rutin respectively have the anti-arthritic activity. This correlation implicates that CRA and rutin in the CH-Ex may be responsible for the activity. Combined all together, the CH-Ex has anti-arthritic activity against C. albi-cans-caused septic arthritis, possibly by inhibiting NO production and proliferation of T cells. This activity seems to be con-tributed by, at least, CRA and rutin among the compounds in the CH-Ex.

목차

실험재료 및 방법

실험결과 및 고찰

결 론

References

키워드

chamomille flowers extract Candida albicans septic arthritis macrophage T lymphocyte chlorogenic acid rutin