더덕 물 추출물과 에탄올 추출물의 인지능 개선 활성 비교

• 영문명: Effect of Water and Ethanol Extracts Codonopsis lanceolata on Spatial Learning and Memory in Mice
• 발행기관: 대한약학회
• 저자명: 원진배 이지우 엄민례 정윤식 고현정 이현용 박동식 정희철 정재윤 마충제
• 간행물 정보: 『약학회지』제58권 제5호 (2014년), 287~293쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.31

영문 초록

Alzheimer’s disease (AD), most common form of dementia is characterized that memory deficit and loss of cog- nitive function. This study was evaluated cognitive enhancing effect of water and ethanol extracts of Codonopsis lanceolata and compared using Morris water maze and passive avoidance test. The water and 70% ethanol extracts (100, 300 and 500 mg/kg) were administered to mice. The neuroprotective effect on glutamate-induced cell death in HT22 cells was addi-tionally investigated using MTT assay. Results showed 70% ethanol extract of Codonopsis lanceolata enhanced cognitive function than water extract, as shown by decrease in escape latency time in Morris water maze test. In passive avoidance test, 70% ethanol extract also increased the latency time compared to the water extract. Furthermore, 70% ethanol extract significantly protected neuronal cell against glutamate cytotoxicity and showed higher than neuroprotective effect of water extract. These results indicate that 70% ethanol extract more improve spatial cognitive ability and protected neuronal cells than water extract.

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키워드

Codonopsis lanceolata cognitive enhancing effect neuroprotective effect