브로콜리 유래 Sulforaphane의 혈관 수축성 조절 효과

• 영문명: The Inhibitory Effect of Broccoli in Cruciferous Vegetables Derived-Sulforaphane on Vascular Tension
• 발행기관: 대한약학회
• 저자명: 제현동
• 간행물 정보: 『약학회지』제58권 제4호 (2014년), 223~228쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.08.31

영문 초록

The present study was undertaken to investigate the influence of sulforaphane on vascular smooth muscle con- tractility and to determine the mechanism involved. We hypothesized that sulforaphane, the primary ingredient of broccoli of cruciferous vegetables, plays a role in vascular relaxation through inhibition of Rho-kinase in rat aortae. Intact of denuded arterial rings from male Sprague-Dawley rats were used and isometric tensions were recorded using a computerized data acquisition system. Interestingly, sulforaphane significantly inhibited fluoride, phorbol ester or thromboxane A2 mimetic-induced contraction in denuded muscles suggesting that additional pathways different from endothelial nitric oxide synthesis such as inhibition of Rho-kinase or MEK might be involved in the vasorelaxation. Furthermore, sulforaphane inhibited thromboxane A2-induced increases in pERK1/2 levels suggesting the mechanism including inhibition of thromboxane A2-induced increases in ERK1/2 phosphorylation. This study provides evidence that sulforaphane induces vascular relaxation through inhibition of Rho-kinase or MEK in rat aortae.

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키워드

endothelium fluoride MEK phorbol ester Rho-kinase sulforaphane vasoconstriction