Chenodeoxycholic Acid에 의한 파골전구세포의 증식 조절

• 영문명: The Regulatory Role of Chenodeoxycholic Acid on the Proliferation of Osteoclast Precursor Cells
• 발행기관: 대한약학회
• 저자명: 노아롱새미 임미정
• 간행물 정보: 『약학회지』제58권 제3호 (2014년), 165~170쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.06.30

영문 초록

We investigated the effect of Chenodeoxycholic acid (CDCA) on the proliferation of osteoclast precursor cells. CDCA decreased the proliferation of osteoclast precursor cells through the control of cell cycle regulators such as cyclin D1, p21 and p27. When we checked the signaling pathway, CDCA decreased Erk activation in osteoclast precursor cells. Furthermore, two bile acid receptors, FXR and TGR5, were involved in the suppressive effect of CDCA. Taken together, this study suggested that bile acid plays an important role in the proliferation of osteoclast precursor cells.

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키워드

CDCA osteoclast precursor cells proliferation