임상에서 분리된 Acinetobacter baumannii의 항생제 내성 패턴과 유전학적 특징

• 영문명: Antibiotic Resistant Patterns and DNA Fingerprint Analysis of Acinetobacter baumannii from Clinical Isolates
• 발행기관: 대한약학회
• 저자명: 김민지 이시원 이도경 박재은 강주연 박일호 신혜순 하남주
• 간행물 정보: 『약학회지』제57권 제2호 (2013년), 132~138쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Acinetobacter baumannii is gram-negative bacilli that can be widely found in environments. Recently, A. bau- mannii emerged as a serious nosocomial infection. A total of 92 A. baumannii were isolated from hospitalized patients in Seoul, Korea, between December 2010 and April 2011. Antimicrobial susceptibility testing was investigated using CLSI agar dilution methods. Tigecycline non-susceptible A. baumannii isolates were investigated by repetitive extragenic palindromic sequence-based PCR (rep-PCR). Pulsed-field gel electrophoresis was performed to determine the epidemiological rela- tionships. All clinical isolates showed high-level resistance to the most commonly used antibiotics: Ciprofloxacin (87.0%), Ampicillin/sulbactam (82.6%), Cefotaxime (81.5%), Ceftazidime (80.4%). Moreover, 50.0% of these isolates were non-sus- ceptible to tigecycline. When evaluated by RAPD analysis, generated distinct band ranging in size from 1kb to 8k band vary- ing from 4 to 10 bands. Stricter surveillance and more rapid detection are essential to prevent the spread of multi drug resistant A. baumannii.

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감사의 글

참고문헌

키워드

Acinetobacter baumannii Antibiotic resistance rep-PCR RAPD analysis