새로운 옥사졸리디논계 항균제 LCB01-0183의 항균 활성

• 영문명: Antimicrobial Activities of LCB01-0183, a New Oxazolidinone
• 발행기관: 대한약학회
• 저자명: 이현희 정성지 정지웅 조영락 김용주 곽진환
• 간행물 정보: 『약학회지』제57권 제2호 (2013년), 95~100쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

This study was performed to analyze in vitro and in vivo activities of LCB01-0183, a new oxazolidinone, against clinical isolates of bacteria. In vitro antibacterial activity of LCB01-0183 was tested by the two fold agar dilution method. In vivo activity of LCB01-0183 was determined against systemic infections in mice. LCB01-0183 showed most potent activ-ity among the test compounds against clinical isolates of Gram-positive bacteria. Furthermore, the protective activity of LCB01-0183 was very effective against systemic infections in mice by oral or subcutaneous administration. In time kill study, LCB01-0183 showed a bacteriostatic activity during 24 hours. LCB01-0183 had potent in vitro and in vivo activity against Gram-positive bacteria including drug-resistant strains.

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키워드

LCB01-0183 antibacterial activity MIC time-kill oxazolidinone