흰 쥐의 선상 절개 창상모델에서 저출력 레이저 자극이 조직 염증반응에 미치는 영향

• 영문명: The Effects of Low Power Laser Treatment on Tissue Inflammatory Reactions in the Linear Incision Wound on Rat Skin
• 발행기관: 한국전문물리치료학회
• 저자명: 임인혁(Lim In-hyuk) 이정원(Lee Jeong-Weon) 김현숙(Kim Hyun-sook)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제10권 제2호, 61~70쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

The purposes of this study was to evaluate the effect of low power GaAsAl laser on tissue contraction in a linear incision wound on rat skin. The linear incision wound was made on the midline of the backside in the experimental animals. Low power laser applications with different intensities such as 3, 6, or 10 ㎽ were applied to the experimental animals twice a day for 10 days. On either the seventh or tenth postoperative day, the quantitative analysis of the inflammatory reaction surrounding the linear incision wounds on the rats were performed using enzymatical analysis of myeloperoxidase (MPO) activity. The number of neutrophil was .07-1.0 × 106/㎖ from a normal blood sample that was obtained from the normal experimental animals. Each concentration of neutrophil showed .04-.62 unit activity of MPO. Therefore, the unit activity of MPO per neutrophil was .57±.014 × 10^-6 unit. On the 7th and 10th post operative day, non treated tissues demonstrated increased MPO activity as compared to that of normal tissue. These data indicated that the inflammatory reaction of tissue was induced after wound induction and the MPO activity were increased in the inflammed tissues. While both 3 ㎽ or 6 ㎽ intensity of laser treatments did not affect the tissue MPO activity, 10 ㎽ intensity of laser treatment significantly decreased the tissue MPO activity on the 7th and 10th post operative day. These data demonstrated that only 10 ㎽ intensity of laser treatment successfully suppressed tissue inflammatory reaction after wound induction. In conclusion, these findings suggested that 10 ㎽ of GaAlAs laser treatments effectively suppressed the inflammatory reaction of tissue that was induced during the wound healing process.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Enzyme activity GaAlAs laser Inflammatory reaction Myeloperoxidase Neutrophil Wound healing