주요우울증과 혈관성우울증에서 뇌자기공명영상내 백질병소의 비교

• 영문명: Comparison of White Matter Lesions on the Magnetic Resonance Imaging in Major Depression and Vascular Depression
• 발행기관: 대한노인정신의학회
• 저자명: 전진숙(Jin-Sook Cheon)
• 간행물 정보: 『노인정신의학』노인정신의학 제3권 제1호, 59~69쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1999.06.30

영문 초록

Objectives : The aims of this study were to identify the frequency and severity of white matter lesions on MRIs of late-life depression and deppression due to cerebrovascular diseases (vascular depression), to evaluate the relation with cerebrovascular risk factors, and finally to understand an important cause of late-life depression. Design : The frequency and severity of the periventricular hyperintensity and the deep white matter hyperintensity were measured on the brain MRIs in the patients with major depression, vascular depression and neurotic controls over 50 yrs of age. The association of the white matter lesions with cerebrovascular risk factors were evaluated. Materials and Methods : The MRI films of 32 patients (15 males & 17 females) with major depression over 50 yrs of age, 25 patients (17 males & 8 females) with vascular depression, and 25 neurotic controls (6 males & 19 females) were analyzed for the white matter lesions according to the modified Fazekas criteria. The cerebrovascular risk factors including hypertension, arteriosclerosis, obesity, smoking, diabetes mellitus, thyroid function abnoramlities, EKG abnormality, stroke, etc were also assessed. Results : 1) The frequency of periventricular lesions or deep white matter lesions were significantly higher in patients with vascular depression and major depression than in neurotic controls. 2) The intracerebral hyperintensities or classical infarctions were prevalent in frontal cortex (32.0%) and in basal ganglia (40.0%). 3) Among cerebrovascular risk factors, stroke (p<0.005), hypertension (p<0.025), EKG abnormality (p<0.005) and smoking (p<0.05) were significantly prevalent in the patients with vascular depression and major depression as compared with neurotic controls. 4) The severity of white matter lesions were significantly asso-ciated with the cerebrovascular risk factors (p<0.005) in patients with major depression over 50 yrs of age. Conclusions : The white matter hyperintensities on brain MRIs of patients with major depression over 50 yrs of age were significantly associated with cerebrovascular risk factors, which suggested a vascular origin of pathogenesis of late-life depression.

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노년기우울증 혈관성우울증 뇌자기공명영상검사 뇌실변 고음영 심부백질 고음영 뇌혈관장야 위험인자 Late-life depression Vascular depression Brain MRIs Periventricular hyperintensities Deep white matter hyperintensities Cerebrovascular risk factors