알쯔하이머병 환자에서 백질 변화와 혈중 호모시스테인 및 엽산 농도의 상관관계

• 영문명: Correlation of Plasma Homocysteien and Folate Levels with White Matter Changes in Alzheimer's Disease Patients
• 발행기관: 대한노인정신의학회
• 저자명: 김신겸(Shin Gyeom Kim) 정한용(Han Yong Jung) 이소영(So Young Lee) 신은영(Eun Young Shin) 정우열(Woo Yeol Jung) 박준호(Jun Ho Park)
• 간행물 정보: 『노인정신의학』노인정신의학 제13권 제2호, 83~90쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.12.30

영문 초록

Objectives : To explore the relationship of white matter changes (WMC) on magnetic resornance imaging (MRI) with plasma homocysteine and folate levels in Alzheimer's disease (AD) patients. Methods : Forty-one patients with probable AD were evaluated on WMC on brain MRI, plasma homocysteine and folate levels, and cerebrovascular risk factors. Subjects were divided into two groups according to WMC scores (lower group with <5 and higher group with ≥5). WMC were assessed by a scale of the European Task Force on Age-Related WMC. Results : Plasma homocysteine levels were correlated with right frontal WMC and have a tendency of correlation with left frontal WMC. When subjects were divided into two groups: higher plasma homocysteine group (≥14 μmol/L) and lower plasma homocysteine group (<14 μmol/L), the former was significantly higher than the latter in both frontal WMC. In a logistic regression analysis, higher plasma homocysteine were not a significant risk factor for higher WMC. Increasing age was a only significant risk factor for higher WMC and correlated with both frontal WMC. There was no relationship folate with any WMC. Conclusion : It is possible that plasma homocysteine levels have a region-specific correlation with frontal WMC in AD. However, it is important that effect of age on the relationship should be considered.

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키워드

신경심리학적 평가 알쯔하이머병 White matter changes Homocysteine Alzheimer's disease CDR