주요우울장애 환자에서 Brain-Derived Neurotrophic Factor 유전자 다형성과 선택적 세로토닌 흡수 차단제의 치료반응도간의 연관성 연구

• 영문명: Association Study Between Brain-Derived Neurotrophic Factor Genetic Polymorphism and Treatment Responses of Selective Serotonin Reuptake Inhibitor in Major Depressive Disorder
• 발행기관: 대한노인정신의학회
• 저자명: 이영민(Young Min Lee)
• 간행물 정보: 『노인정신의학』노인정신의학 제12권 제1호, 34~39쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Objectives : Recent studies suggest that brain-derived neurotrophic factor (BDNF) may play a critical role in both mechanism of antidepressant action and the pathophysiology of major depressive disorder (MDD). The aim of this study is to evaluate whether the BDNF-gene Val66Met polymorphism is associated with susceptibility of MDD, and antidepressant response in a Korean population. Methods : To explain genetic susceptibility of MDD, we genotyped the BDNF-gene Val66Met polymorphism in 137 patients with MDD and 91 age- and sex-similar control subjects. we also examined the association of the BDNF-gene Val66Met polymorphism and therapeutic response in 137 MDD patients who received a 6-week Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Results : There were no significant differences in the genotype or allele frequency of the BDNF polymorphism, between the MDD and control subjects. Furthermore, no significant differences were noted in the three-genotype groups (Val/Val, Val/Met, Met/Met) between responders and non-responders. However, heterozygous patients (Val/Met) in comparison to homozygous analogs (Val/Val or Met/Met) in BDNF polymorphism tended to have more improved 6-week antidepressant response (p=0.053). In addition, higher total HAM-D-score percentage change after 6 weeks of antidepressant medication was demonstrated for the heterozygote patients in comparison to homozygous analogs (p=0.006). Conclusion : This finding suggests the BDNF polymorphism is associated with improved therapeutic SSRI response for patients bearing the BDNF Val/Met heterozygote in comparison to the homozygous analogs.

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유전자 다형성 주요우울장애 선택적세로토닌흡수차단제 Brain-derived neurotrophic factor BDNF Val66Met polymorphism Major depressive disorder Selective Serotonin Reuptake Inhibitor