알츠하이머병 환자에서 콜린아세틸전이효소(ChAT) 유전자 다형성과 갈란타민 치료 반응도 간의 연관성 연구

• 영문명: A Study on the Association Between Cholineacetyltransferase(ChAT) Polymorphism and Treatment Responses of Galantamine in Alzheimer's Disease Patients
• 발행기관: 대한노인정신의학회
• 저자명: 이영민(Young Min Lee) 서만길(Man Kil Seo) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제12권 제1호, 28~33쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Cholineacetyltrasnferase (ChAT) is a key enzyme that facilitates synthesis of acetylcholine affecting the memory, learning, awakening and sleep process of the cerebrum. The object of this study was to test the hypothesis that the ChAT-gene 2384G>A (rs3810950) polymorphism is associated with Alzheimer's disease (AD) susceptibility, and galantamine response. To elucidate a genetic predisposition of AD, we studied ChAT-gene 2384G>A (rs3810950) polymorphism in 52 AD patients in 93 normal controls. We also examined the association of this polymorphism and galantamine therapeutic response in 52 AD patients who received a 24-week galantamine treatment. There were no significant differences in the genotype or allele frequency of the ChAT polymorphism between the AD and control groups. However, we found that the allele-carrier distributions, allele frequency for the ChAT polymorphism differed significantly between responders and non-responders. The frequency of A-allele carriers (GA+AA) was higher in responders than in non-responders (χ2=4.282, df=1, p=0.039), as was the A-allele frequency (χ2=5.216, df=1, p=0.022). These results suggest that the ChAT-gene 2384G>A (rs3810950) polymorphism is associated with galantamine therapeutic response.

목차

서 론

방 법

결 과

고 찰

키워드

콜린아세틸전이효소 알츠하이머 병 유전자다형성 갈란타민 치료반응도 Cholineacetyltransferase Alzheimer's disease Gene polymorphism Galantamine Therapeutic response