Bisdemethoxycurcumin Inhibits Lipopolysacchaide-induced Nitric Oxide Production by Inhibiting Nuclear Factor-kappa B in RAW264.7 Macrophages

• 발행기관: 강원대학교 기초과학연구소
• 저자명: An Na Kim Byung-Chul Kim
• 간행물 정보: 『기초과학연구』제20집, 189~196쪽, 전체 8쪽
• 주제분류: 자연과학 > 자연과학일반
• 파일형태: PDF
• 발행일자: 2009.12.30

영문 초록

We here demonstrate an anti-inflammatory action of bisdemethoxycurcumin(BDMC), an analog of curcumin, in lipoplysaccharide(LPS)-induced murine macrophage RAW264.7 cells. Treatment with BDMC at micromolar concentrations suppressed the production of nitric oxide by down-regulating expression of the inducible nitric oxide synthase (iNOS) gene in LPS-stimulated macrophages. The decreased expression of iNOS and subsequent reduction of NO were due to inhibition of nuclear factor kappa B(NF-kB) activity but not c-Jun NH2-terminal kinase 1.2 (JNK1.2) activity, which were activated in the LPS-activated macrophages. Thus our findings indicate that BDMC exerts its anti-inflammatory action by blocking the NF-kB activi쇼, and eventually reduces expression of pro-inflammatory genes such as iNOS.