학술논문
Relationship Between Brain-Derived Neurotrophic Factor and Cognitive Function in Methamphetamine-Dependent Patients
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Hwallip Bae Sung-Doo Won Jiyoun Kim Hye-Jin Seo Changwoo Han
- 간행물 정보
- 『Psychiatry Investigation』제22권 제3호, 252~257쪽, 전체 6쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2025.03.18
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국문 초록
Consequently chronic METH use can affect the cognitive functions in METH-dependent patients. In this study, we aimed to identify the relationship between cognitive function and brain-derived neurotrophic factor (BDNF), which reflects the status of neuroadaptive changes, by characterizing the effects on the cognitive function of METH-dependent patients.
Methods A total of 38 METH-dependent patients participated in this study. BDNF levels were measured using the enzyme-linked immunosorbent assay. We also examined the clinical features based on the measurements of the Consortium to Establish a Registry for Alzheimer’s Disease-Korean version (CERAD-K). Finally, the relationships between various parts of CERAD-K and BDNF were compared with one another.
Results METH-dependent patients were able to conduct most parts of CERAD-K stably. Among the parts of CERAD-K, only trail-making test part B was correlated with BDNF.
Conclusion The trail-making test is specific for evaluating executive function; therefore, BDNF may play an essential role in detecting neurocognitive functional decline in METH dependence.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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