학술논문
Microglial galectin-3 increases with aging in the mouse hippocampus
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- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Hyun Joo Shin So Jeong Lee Hyeong Seok An Ha Nyeoung Choi Eun Ae Jeong Jaewoong Lee Kyung Eun Kim Bong-Hoi Choi Seung Pil Yun Dawon Kang Sang Soo Kang Gu Seob Roh
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제29권 제2호, 215~225쪽, 전체 11쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2025.03.01
4,120원
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국문 초록
Microglial activation during aging is associated with neuroinflammation and cognitive impairment. Galectin-3 plays a crucial role in microglial activation and phagocytosis. However, the role of galectin-3 in the aged brain is not completely understood. In the present study, we investigated aging-related mechanisms and microglial galectin-3 expression in the mouse hippocampus using female 6-, 12-, and 24-month-old C57BL/6 mice. Western blot analysis revealed neurodegeneration, blood-brain barrier leakage, and increased levels of neuroinflammation-related proteins in 24-month-old mice compared to 6- and 12-month-old mice. Immunohistochemistry revealed an increase in activated microglia in the hippocampus of 24-month-old mice compared to 6- and 12-month-old mice. Furthermore, we found more galectin-3 and triggering receptor expressed on myeloid cells-2-positive microglia in 24-month-old mice compared to 6- and 12-month-old mice. Using primary mouse microglial cells, galectin -3 was also increased by lipopolysaccharide treatment. These findings suggest that galectin-3 may play an important role in microglial activation and neuroinflammation during brain aging.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
FUNDING
ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST
REFERENCES
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