Functional interplay between non-canonical inflammasomes and autophagy in inflammatory responses and diseases

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Young-Su Yi
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제29권 제2호, 129~138쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.03.01

국문 초록

The inflammasome is a cytosolic multiprotein platform that plays a key role in the inflammatory response, an essential innate immune response that protects the body from pathogens and cellular danger signals. Autophagy is a fundamental cellular mechanism that maintains homeostasis through the elimination and recycling of dysfunctional molecules and subcellular elements. Many previous studies have demonstrated a functional interplay between canonical inflammasomes that were earlier discovered and autophagy in inflammatory responses and diseases. Given the increasing evidence that non-canonical inflammasomes are unique and key factors in inflammatory responses, the functional interplay between non-canonical inflammasomes and autophagy is noteworthy. Recent studies have demonstrated that non-canonical inflammasomes and autophagy are functionally correlated with inflammatory responses and diseases. This review comprehensively discusses recent studies that have investigated the functional interplay of non-canonical inflammasomes, such as mouse caspase-11 and human caspase-4, with autophagy and autophagy-related proteins in inflammatory responses and diseases and provides insight into the development of novel anti-inflammatory therapeutics by modulating the functional interplay between non-canonical inflammasomes and autophagy.

목차

INTRODUCTION

NON-CANONICAL INFLAMMASOMES AND INFLAMMATORY RESPONSES

FUNCTIONAL INTERPLAY BETWEEN NONCANONICAL INFLAMMASOMES AND AUTOPHAGY

CONCLUSION

FUNDING

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Autophagy Caspase-4 Caspase-11 Inflammation Non-canonical inflammasome