Neurosteroids and neurological disorders

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Gi Wan Park Hayoung Kim Seong Hyun Won Nam Hyun Kim Sheu-Ran Choi
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제29권 제2호, 157~164쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.03.01

국문 초록

Neurosteroids play an important role as endogenous neuromodulators that are locally produced in the central nervous system and rapidly change the excitability of neurons and the activation of microglial cells and astrocytes. Here we review the mechanisms of synthesis, metabolism, and actions of neurosteroids in the central nervous system. Neurosteroids are able to play a variety of roles in the central nervous system under physiological conditions by binding to membrane ion channels and receptors such as gamma-aminobutyric acid type A receptors, Nmethyl- D-aspartate receptors, L- and T-type calcium channels, and sigma-1 receptors. In addition, numerous neurological disorders, including persistent neuropathic pain, multiple sclerosis, and seizures, have altered the levels of neurosteroids in the central nervous system. Thus, we review how local synthesis and metabolism of neurosteroids are modulated in the central nervous system and describe the role of neurosteroids under pathological conditions. Furthermore, we discuss whether neurosteroids may play a role as a new therapeutic for the treatment of neurological disorders.

목차

INTRODUCTION

NEUROSTEROIDOGENESIS

NEUROSTEROIDS-INDUCED MODULATION OF RECEPTORS

NEUROSTEROIDS AND NEUROPATHIC PAIN

NEUROSTEROIDS AND MULTIPLE SCLEROSIS

NEUROSTEROIDS AND SEIZURES

CONCLUSION

FUNDING

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Nervous system diseases Neurosteroids Receptors GABA Receptors N-methyl-D-aspartate Sigma-1 receptor