The effect of the timing of iron administration on the outcome of photodynamic therapy using photolon in the CT26 colorectal cancer mouse model

• 발행기관: 조선대학교 의학연구원
• 저자명: Soo-Min Heo Tae-Gyu Ahn So-Ra Yang Hyunju Liu
• 간행물 정보: 『Medical Biological Science and Engineering』제7권 제1호, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.01.31

국문 초록

Photodynamic therapy (PDT) is a minimally invasive cancer treatment undergoing research to in-crease its therapeutic effect. This study investigated the effect of iron administration time on the anticancer effects of PDT. Inflammation-related gene expression in tumor tissue was measured using RNA sequencing. Comparison of the PDT and Fe groups revealed that tumor volume increased 2.75 times in the PDT group after 14 d of PDT, with no difference between the PDT and 24hFe+PDT groups, while in the 1hFe+PDT group tumor vol-ume decreased 0.49 times. After 24 h of PDT, the 8-OHdG and TBARS content in the tumor tissue increased by 60% and 68% respectively in the 1hFe+PDT group compared with the PDT group, with no difference observed between the PDT and 24hFe+PDT groups. Gene expression was significantly increased in the 1hFe+PDT group 24 h after PDT and included Ccl12, Cxcl1, Cxcl2, Cxcl5, IL1b, and Il6, which are related to the inflammatory response in tumor tissues. Iron administration 1 h before PDT increased the anticancer effect of PDT probably as a result of in-creased oxidative damage.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

키워드

PDT Iron CT26 cell Photolon