학술논문
The Slough of Cicadidae Periostracum Ameliorated Lichenification by Inhibiting Interleukin (IL)- 22/Janus Kinase (JAK) 1/Signal Transducer and Activator of Transcription (STAT) 3 Pathway in Atopic Dermatitis
이용수 3
- 영문명
- 발행기관
- 한국축산식품학회
- 저자명
- Ganghye Park Namgyu Kwon Mi Hye Kim Woong Mo Yang
- 간행물 정보
- 『Food Science of Animal Resources』Food Science of Animal Resources 제43권 제5호, 859~876쪽, 전체 18쪽
- 주제분류
- 농수해양 > 식품과학
- 파일형태
- 발행일자
- 2023.09.01
4,960원
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국문 초록
영문 초록
It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of Cryptotympana pustulata, has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study is aimed at investigating the ameliorating effects of CP on AD and its potential mechanism. The dinitrochlorobenzene sensitized mice were treated with CP for 2 weeks. The various biomarkers and the dermatitis scores presented that CP treatment can induce the visual and biological improvements of AD model. Pruritus, the most serious symptom of AD, which can cause repeated scratching behaviors and finally lead to lichenification, was reduced with CP treatment by regulating the inflammatory reactions. In addition, CP treatment diminished the number of mast cells that are known for causing inflammatory reactions. Moreover, it is proven that CP can decline secretion of interleukin-22, which means CP treatment has anti-inflammatory effects. CP treatment can correct the imbalance of helper T (Th)1 and Th2, downregulating thymic stromal lymphopoietin that leads to decrease of mRNA level of inflammatory cytokines. The crucial role of CP treatment is controlling of the Janus kinase 1/signal transducer and activator of transcription 3 pathway. In addition, CP treatment has the inhibitory effects on kallikrein related peptidase (KLK) 5 and KLK7. Taken together, CP treatment can ameliorate most symptoms and problems caused by AD disease, improving the AD patients’ life quality.
목차
Introduction
Materials and Methods
Results
Discussion
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- The Slough of Cicadidae Periostracum Ameliorated Lichenification by Inhibiting Interleukin (IL)- 22/Janus Kinase (JAK) 1/Signal Transducer and Activator of Transcription (STAT) 3 Pathway in Atopic Dermatitis
참고문헌
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