학술논문
Effect Modification of Cortisol on the Associations Between Obsessive-Compulsive Symptoms on Suicidality in Patients With Acute Coronary Syndrome
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- 영문명
- Effect Modification of Cortisol on the Associations Between Obsessive-Compulsive Symptoms on Suicidality in Patients With Acute Coronary Syndrome
- 발행기관
- 대한신경정신의학회
- 저자명
- Park Jin-Young Kim Ju-Wan Kang Hee-Ju Choi Wonsuk Lee Ju-Yeon Kim Sung-Wan Shin Il-Seon
- 간행물 정보
- 『Psychiatry Investigation』제20권 제8호, 707~713쪽, 전체 7쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2023.08.31
4,000원
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국문 초록
영문 초록
Objective Obsessive-compulsive symptoms (OCS) and suicidal ideation (SI) are common in patients with acute coronary syndrome (ACS). This study investigated the associations of OCS and serum cortisol levels with SI, and further evaluated the possible modifying effects of cortisol on the associations between OCS and SI in acute and chronic phases of ACS.Methods In total, 969 ACS patients were recruited from a tertiary university hospital in Korea within 2 weeks of disease onset and evaluated in terms of OCS (using the OCS dimension of the Symptom Checklist-90–Revised), serum cortisol levels, and SI (using the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI. Logistic regression analysis was performed with adjustment for covariates.Results Higher OCS was significantly associated with SI both at baseline and follow-up. Serum cortisol showed no such association, but modified the association between OCS and SI. That was the associations were significant only in the higher but not in the lower serum cortisol levels, with significant interaction terms after adjusted for relevant covariates.Conclusion Evaluating OCS and serum cortisol levels at the acute phase could improve the accuracy of clinical predictions of SI both in the acute and chronic phases of ACS.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
SUPPLEMENTARY MATERIALS
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