Shikonin ameliorates salivary gland damage and inflammation in a mouse m odel of Sjögren’s syndrome by modulating MAPK signaling pathway

• 영문명: Shikonin ameliorates salivary gland damage and inflammation in a mouse m odel of Sjögren’s syndrome by modulating MAPK signaling pathway
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Wenjing Guo Xin Wang Chao Sun Jian Wang Tao Wang
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제27권 제4호, 357~364쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2023.07.31

영문 초록

Sjögren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in China. However, the application of Shikonin in SS remains unreported. This study aimed to verify the potential functions of Shikonin in SS progression. Firstly, non-obese diabetic mice were used as the SS mouse model, with C57BL/6 mice serving as the healthy control. It was demonstrated that the salivary gland damage and inflammation were aggravated in the SS mouse model. Shikonin improved salivary gland function decline and injury in the SS mouse model. Moreover, Shikonin reduced inflammatory cytokines and immune infiltration in the SS mouse model. Further experiments discovered that Shikonin attenuated the MAPK signaling pathway in the SS mouse model. Lastly, inhibition of the MAPK signaling pathway combined with Shikonin treatment further alleviated the symptoms of SS. In conclusion, Shikonin ameliorated salivary gland damage and inflammation in a mouse model of SS by modulating the MAPK signaling pathway. Our findings indicate that Shikonin may be a useful drug for SS treatment.

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INTRODUCTION

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FUNDING

ACKNOWLEDGEMENTS

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REFERENCES

키워드

Inflammation Salivary gland Shikonin, Sjogren's syndrome