학술논문
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis
이용수 0
- 영문명
- Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- 정윤아 김원준 신나경 배영민 위진홍
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제27권 제4호, 311~323쪽, 전체 13쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2023.07.31
4,360원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling. These channels are involved in diverse signaling pathways, including cell proliferation, migration, and intracellular calcium dynamics. Consequently, ion channel dysfunction can lead to various diseases. In addition, these channels are present in the plasma membrane and intracellular organelles. However, our understanding of the function of intracellular organellar ion channels is limited. Recent advancements in electrophysiological techniques have enabled us to record ion channels within intracellular organelles and thus learn more about their functions.
Autophagy is a vital process of intracellular protein degradation that facilitates the breakdown of aged, unnecessary, and harmful proteins into their amino acid residues.
Lysosomes, which were previously considered protein-degrading garbage boxes, are now recognized as crucial intracellular sensors that play significant roles in normal signaling and disease pathogenesis. Lysosomes participate in various processes, including digestion, recycling, exocytosis, calcium signaling, nutrient sensing, and wound repair, highlighting the importance of ion channels in these signaling pathways. This review focuses on different lysosomal ion channels, including those associated with diseases, and provides insights into their cellular functions. By summarizing the existing knowledge and literature, this review emphasizes the need for further research in this field. Ultimately, this study aims to provide novel perspectives on the regulation of lysosomal ion channels and the significance of ion-associated signaling in intracellular functions to develop innovative therapeutic targets for rare and lysosomal storage diseases.
목차
INTRODUCTION
HISTORY OF LYSOSOMES
BIOLOGICAL FUNCTIONS OF LYSOSOMES
THE ROLE OF ION CHANNELS IN MAINTAINING LYSOSOMAL FUNCTION
CONCLUSION
FUNDING
ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST
REFERENCES
해당간행물 수록 논문
- Monitoring trafficking and expression of hemagglutinin-tagged transient receptor potential melastatin 4 channel in mammalian cells
- PSME4 determines mesenchymal stem cell fate towards cardiac commitment through YAP1 degradation
- Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells
- Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway
- Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1
- Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn’s disease
- Shikonin ameliorates salivary gland damage and inflammation in a mouse m odel of Sjögren’s syndrome by modulating MAPK signaling pathway
- Hydrogen sulfide ameliorates abdominal aorta coarctation-induced myocardial fibrosis by inhibiting pyroptosis through regulating eukaryotic translation initiation factor 2α phosphorylation and activating PI3K/AKT1 pathway
- Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression
- Involvement of α 1B -adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen
- Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis
- Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
- Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases
참고문헌
관련논문
의약학 > 의학일반분야 BEST
- 교육전담간호사가 주도하는 임상현장교육 프로그램이 신규 간호사의 간호업무성과와 교육 만족도에 미치는 효과
- 간호대학생의 MBTI 성격유형별 의사소통능력, 자아존중감, 학업성취도의 관계
- 일반인을 위한 해부학 만화
의약학 > 의학일반분야 NEW
- Glucocorticoids improve sperm performance in physiological and pathological conditions: their role in sperm fight/flight response
- A comprehensive review of the mental spine
- The anatomical variations of median nerve in Shiraz, Iran
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!