Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder

• 영문명: Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder
• 발행기관: 대한신경정신의학회
• 저자명: Jinyi Kim Chanju Lee Youbin Kang Wooyoung Kang Aram Kim Woo-Suk Tae Byung-Joo Ham Jisoon Chang
• 간행물 정보: 『Psychiatry Investigation』제20권 제3호, 255~261쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.03.31

영문 초록

Objective A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs). Methods A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software. Results No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the “any abuse” and “no abuse” groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679). Conclusion Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Childhood trauma Sexual abuse Depression Major depressive disorder Prefrontal cortex Magnetic resonance imaging