Breviscapine Ameliorates Fear Extinction and Anxiety in BALB/cJ Mice

• 영문명: Breviscapine Ameliorates Fear Extinction and Anxiety in BALB/cJ Mice
• 발행기관: 대한신경정신의학회
• 저자명: Wei Liang Jing Huang Shuya Yang Peng Huang Jun Chen Chen Chen Qun Yang Fengzhan Li
• 간행물 정보: 『Psychiatry Investigation』제20권 제3호, 205~211쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.03.31

영문 초록

Objective In this research, the influence of breviscapine on anxiety, fear elimination, and aggression and the potential mechanism was investigated. Methods Anxiety and locomotion were analyzed by elevated plus maze and open field test in mice. Bussey-Saksida Mouse Touch Screen Chambers were used to perform fear conditioning. Territorial aggression was assessed by resident intruder test. Protein levels were evaluated by Western blot. Breviscapine improved fear-extinction learning in BALB/cJ mice. Results Breviscapine at 20-100 mg/kg increased center cross number, total distance traveled, and velocity in a dose-dependent manner. On the other hand, breviscapine at 20-100 mg/kg decreased the immobility time in open field test. In addition, breviscapine at 20-100 mg/kg increased the ratio of time on the open arm, time on the distal parts of the open arm, and total distance traveled in elevated plus maze. Breviscapine at 100 mg/kg increased the average attack latency and decreased the number of attacks over the last 3 days of resident intruder test. In hippocampus, protein levels of postsynaptic density protein-95 and synaptophysin were elevated by breviscapine at these three doses. Conclusion The administration of breviscapine alleviates fear extinction, anxiety, and aggression, while increases locomotor in a dose-dependent manner, which might be associated with its influence on synaptic function.

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INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Breviscapine Attention deficit hyperactivity disorder Conduct disorder BALB/cJ mice Fear extinction