벤조디아제핀

• 영문명: Benzodiazepines: Pharmacology Up-to-Date and Practical Issues
• 발행기관: 대한신경정신의학회
• 저자명: 강웅구 김세현 이남영 이규영 김용식 정인원
• 간행물 정보: 『신경정신의학』제62권 제1호, 1~20쪽, 전체 20쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.02.28

영문 초록

Benzodiazepines have been widely used as anxiolytics, sedatives, hypnotics, anticonvulsants, or central muscle relaxants since the 1960s despite significant adverse effects, the potential for misuse, and consequent overdose. Benzodiazepines exert their pharmacological action by binding to gamma-aminobutyric acid type A (GABA-A) receptors in the brain and facilitateing the inhibitory actions of the neurotransmitter GABA. Recent findings have also elucidated the effects of benzodiazepines on the allosteric modulation of GABA-A receptors, including receptor subtypes and transmembrane proteins, which is a significant step in our understanding of GABA pharmacology. In clinical practice, the use of benzodiazepines to treat psychiatric disorders has been limited due to the challenges associated with the long-term use, namely the risks of abuse, misuse, and overdose, as well as withdrawal effects. Furthermore, the approval of selective serotonin reuptake inhibitors for anxiety disorders has led to their extensive use as a first-line pharmacological option and they have also been promoted in various practice guidelines for the treatment of anxiety disorders. However, although recent systematic reviews and meta-analyses have shown that benzodiazepines are useful and effective drugs for the treatment of various neuropsychiatric disorders, including anxiety, debates over the clinical use of benzodiazepines continue. More than 60 years after the introduction of benzodiazepines in clinical practice, it is necessary to revisit the controversies associated with benzodiazepine use and to update the discussion current approach to practice with thethrough an understanding of the new data on their pharmacological actions and to identify appropriate indications according to the new diagnostic systems of psychiatric disorders through an extensive literature review.

목차

서론

BZD의 역사적 배경

BZD계 약물의 분류

약리학

GABAA 신경전달계 관련 신경정신 장애들

BZD 용량 및 투여 기간과 관계된 문제

BZD 남용과 관계된 논란들

BZD가 퇴조한 이유

역학 조사에서 밝혀지는 BZD의 주요 부작용

결론

REFERENCES

키워드

Psychiatric disorders Benzodiazepine Pharmacology Adverse events