Old Age, Female Sex, and Psychotropic Medications Predict Hyposalivation But Not Heart Rate Variability

• 영문명: Old Age, Female Sex, and Psychotropic Medications Predict Hyposalivation But Not Heart Rate Variability
• 발행기관: 대한신경정신의학회
• 저자명: Seung-Yup Lee Kyu-In Jung Min-Hyeon Park Chang-Uk Lee
• 간행물 정보: 『Psychiatry Investigation』제20권 제1호, 62~68쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.01.31

영문 초록

Objective To explore risk factors for dry mouth and examine the clinical utility of the heart rate variability (HRV) test in the prediction of dry mouth. Methods Every outpatient, who underwent tests for both unstimulated salivary flow and HRV, was retrospectively reviewed. After excluding seven subjects, the demographics and clinical factors in 70 total patients were collected. Based on objective salivary flow rates, patients were classified into normal (≥0.2 mL/min) or hyposalivation groups (<0.2 mL/min), and inter-group comparisons were performed with a two-tailed statistical significance of 0.05. Results Patients with subjective dry mouth were significantly more likely to show hyposalivation. Advanced age, female sex, and current use of psychotropic medications were identified as risk factors for dry mouth. However, dry mouth was not associated with any HRV parameters. Conclusion HRV test did not demonstrate a clinical utility in predicting dry mouth. Because subjective dry mouth is significantly associated with objective hyposalivation, a simple probing question would be useful for early recognition of dry mouth. Clinical attention is required for patients meeting criteria of older age, female, and/or using psychotropic prescriptions. Prompt management of hyposalivation may improve quality of life and clinical outcome by enhanced treatment adherence.

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INTRODUCTION

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키워드

Xerostomia Saliva Pharmacotherapy Drug side effects Autonomic nervous system