Animal Models of Cognitive Deficits for Probiotic Treatment

• 영문명: Animal Models of Cognitive Deficits for Probiotic Treatment
• 발행기관: 한국축산식품학회
• 저자명: Oh Yun Kwon Seung Ho Lee
• 간행물 정보: 『Food Science of Animal Resources』Food Science of Animal Resources 제42권 제6호, 981~995쪽, 전체 15쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2022.11.30

영문 초록

Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and is known to be caused by the structural and functional loss of neurons. Many natural agents that can improve cognitive function have been developed and assessed for efficacy using various cognitive deficit animal models. As the gut environment is known to be closely connected to brain function, probiotics are attracting attention as an effective treatment target that can prevent and mitigate cognitive deficits as a result of neurodegenerative diseases. Thus, the objective of this review is to provide useful information about the types and characteristics of cognitive deficit animal models, which can be used to evaluate the anti-cognitive effects of probiotics. In addition, this work reviewed recent studies describing the effects and treatment conditions of probiotics on cognitive deficit animal models. Collectively, this review shows the potential of probiotics as edible natural agents that can mitigate cognitive impairment. It also provides useful information for the design of probiotic treatments for cognitive deficit patients in future clinical studies.

목차

Introduction

Chemical-Induced Cognitive Deficit Animal Models for Probiotic Treatment

Transgenic Animal Models that Have Cognitive Deficit Phenotypes

Conclusion

Conflicts of Interest

Acknowledgements

Author Contributions

Ethics Approval

References

키워드

cognitive deficits probiotics neurodegenerative disease gut-brain axis