Distinct cell populations of ventral tegmental area process motivated behavior

• 영문명: Distinct cell populations of ventral tegmental area process motivated behavior
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Min Jung Kim 강봉균(Bong-Kiun Kaang)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제26권 제5호, 307~312쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2022.09.30

영문 초록

It is well known that dopamine transmission from the ventral tegmental area (VTA) modulates motivated behavior and reinforcement learning. Although dopaminergic neurons are the major type of VTA neurons, recent studies show that a significant proportion of the VTA contains GABAergic and type 2 vesicular glutamate transporter (VGLUT2)-positive neurons. The non-dopaminergic neurons are also critically involved in regulating motivated behaviors. Some VTA neurons appear to co-release two different types of neurotransmitters. They are VGLUT2-DA neurons, VGLUT2-GABA neurons and GABA-DA neurons. These co-releasing neurons show distinct features compared to the neurons that release a single neurotransmitter. Here, we review how VTA cell populations wire to the other brain regions and how these projections differentially contribute to motivated behavior through the distinct molecular mechanism. We summarize the activities, projections and functions of VTA neurons concerning motivated behavior. This review article discriminates VTA cell populations related to the motivated behavior based on the neurotransmitters they release and extends the classical view of the dopamine-mediated reward system.

목차

INTRODUCTION

DOPAMINERGIC NEURONS OF THE VTA

GLUTAMATERGIC NEURONS OF VTA

GABAERGIC NEURONS OF VTA

CONCLUSIONS AND PERSPECTIVES

FUNDING

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Dopamine GABA Glutamate Motivation Ventral tegmental area