Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia

• 발행기관: 대한신경정신의학회
• 저자명: Jie Shen Guangfan Shen Woo-Sung Kim Uyanga Tsogt Congcong Liu Jing Sui Young-Chul Chung
• 간행물 정보: 『Psychiatry Investigation』제18권 제4호, 284~299쪽, 전체 16쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.04.30

영문 초록

Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based fMRI procedure. Methods This study included 50 patients with SSDs and 52 controls. The schema-evoking task consisted of four active conditions and neutral condition. Differences in brain activation were compared between the two groups. Correlation analysis was performed between task-related activation and psychopathology. Results The SSD patients exhibited higher activity of the left middle and inferior frontal gyri under the negative-others minus neutral contrast as well as greater activation of the left superior and middle frontal gyri and right medial superior frontal gyrus under the posi-tive-self minus neutral and positive-others minus neutral contrasts. Under the positive-others minus neutral contrast, negative correlation was observed between activity of the right inferior parietal gyrus and right angular and total score of the Positive and Negative Syndrome Scale (PANSS), whereas positive correlation between activity of the left middle cingulate gyrus and left/right precuneus and positive-oth-ers score of the Brief Core Schema Scales (BCSS). Conclusion The present findings suggest that the frontal brain regions of SSD patients are more sensitive to negative and positive sche-mas towards the self and/or others compared to those of controls. Psychiatry Investig 2021;18(4):284-294

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Negative schema Positive schema Schizophrenia fMRI