The effect of using nefopam in fentanyl-based intravenous patient-controlled analgesia on the incidence of postoperative nausea and vomiting in laparoscopic gynecological surgery

• 발행기관: 조선대학교 의학연구원
• 저자명: YoonJu Go Jun-Young Chung Jae-woo Yi Bong-Jae Lee Hyungseok Seo
• 간행물 정보: 『Medical Biological Science and Engineering』제4권 제1호, 20~26쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.01.31

영문 초록

Currently, the regimen of intravenous patient-controlled analgesia (IV-PCA) has become lowering opioid to reduce opioid-related side effects, particularly, postoperative nausea and vomiting (PONV). Using nefopam in IV-PCA may decrease the incidence of PONV, but there is still a lack of evidence. 178 patients undergoing laparoscopic gynecological surgery were randomly assigned into two groups. The IV-PCA regimen for group F was 20 mg/kg fentanyl and for group N was 10 mg/kg fentanyl with 200 mg of nefopam. The severity of PONV and pain were assessed at both 1 hour and 24 hours after surgery. Patients’ satisfaction with recovery was evaluated by a structured questionnaire. The incidence of PONV showed no statistical difference between group N and group F (28.2% vs. 26.8% at 1 hour, p=0.839 and 32.1% vs. 43.9% at 24 hours, p=0.120, respectively). Also, postoperative pain intensity showed no statistical difference between the two groups. Patient recovery was similar between the two groups. The combined use of nefopam in IV-PCA seems to effectively decrease the fentanyl dose in laparoscopic gynecological surgery. However, it did not contribute to decreasing the incidence of PONV.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

키워드

Patient-controlled analgesia Fentanyl Postoperative nausea and vomiting Nefopam