방풍통성산 및 대시호탕의 항비만효과 분석

• 영문명: The Anti-obesity Effects of Bangpungtongseong-san and Daesiho-tang: A Study Protocol of Randomized, Double-blinded Clinical Trial
• 발행기관: 한방비만학회
• 저자명: 오지홍(Jihong Oh) 심혜윤(Hyeyoon Shim) 차지윤(Jiyun Cha) 김호석(Ho Seok Kim) 김민지(Min Ji Kim) 안은경(Eun Kyung Ahn)
• 간행물 정보: 『대한한방비만학회지』제20권 2호, 138~148쪽, 전체 11쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2020.12.03

영문 초록

Objectives: The aim of this study is to evaluate the effects of Bangpungtongseong-san (Fangfengtongsheng-san, BTS) and Daesiho-tang (Dachaihu-tang, DST) on weight loss and improvement in lipid metabolism and glucose metabolism. Furthermore, we intend to develop a prediction model for drug effects through the analysis of the single nucleotide polymorphism (SNP), gut-microbiota, and the expression of immune-related biomarkers. Methods: This study is a single-center, randomized, double-blind, parallel-design clinical trial. One hundred twenty-eight participants will be assigned to the BTS group (n=64) and DST group (n=64). Both groups will be administered 4 g medication three times a day for up to 2 weeks. The primary outcomes is weight loss. The secondary outcomes include bioelectrical impedance analysis, waist circumstance, body mass index, total cholesterol, high-density lipoprotein, triglyceride, insulin resistance. The exploratory outcomes include 3-day dietary recall, food frequency questionnaire, quality of life questionnaire, gut microbiota analysis, immune biomarkers analysis, and SNP analysis. Assessment will be made at baseline and at week 4, 8, and 12. Conclusions: This protocol will be implemented by approval of the Institutional Review Board of Dongguk University. The results of this trial will provide a systematic evidence for the treatment of obesity and enable more precise herbal medicine prescriptions.

목차

서론

대상 및 방법

고찰

References

키워드

Obesity Korea traditional medicine Randomized controlled trial Herbal medicine