纈草根 메탄올 추출물이 고지혈증 유발 생쥐의 지질대사에 미치는 영향

• 영문명: Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice
• 발행기관: 한방비만학회
• 저자명: 박선미(Sun Mi Park) 김영균(Young Kyun Kim) 유선애(Sun Ae Yu) 조성우(Sung Woo Cho) 이명화(Myeong Hwa Lee) 임재은(Jae Eu
• 간행물 정보: 『대한한방비만학회지』제20권 2호, 88~96쪽, 전체 9쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2020.12.03

영문 초록

Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice. Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured. Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly. Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.

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키워드

Valeriana fauriei Briquet Valerianae Radix et Rhizoma Hyperlipidemias