정신건강의학과 환자에서의 Liraglutide의 효과 및 안전성

• 영문명: Effectiveness and Safety of Liraglutide Treatment in Patients with a Psychiatric Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 최영재(Young Jae Choi) 이중선(Jungsun Lee) 박소연(Soyeon Park) 강유리(Yuree Kang) 주성우(Sung Woo Joo)
• 간행물 정보: 『신경정신의학』제59권 제4호, 325~330쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2020.11.30

영문 초록

Objectives Liraglutide is a glucagon-like-peptide-1 receptor agonist which has been used as an anti-obesity drug. It was reported that patients might develop or worsen suicidal ideas and/or depression during liraglutide treatment, especially when it comes to patients with a psychiatric disorder. The purpose of this study was to evaluate the effectiveness and safety of liraglutide, especially in terms of the psychiatric adverse effects. Methods A retrospective chart review study was conducted on psychiatric patients prescribed liraglutide for more than one month from September 2018 to September 2020. Based on their medical records, we investigated the change in the weight and body mass index (BMI) of patients from the baseline to 6 months of receiving liraglutide treatment. Information on the adverse effects was also obtained, including psychiatric adverse effects such as insomnia, anxiety, depression, and suicidal ideation. A mixed linear model was used for assessing the time effect on change in weight and BMI. Results A total of 24 patients were included in the current study, and the most common psychiatric diagnosis included major depressive disorder (n=13, 54.2%). There was a significant change in weight (F=6.127, p=0.001) and BMI (F=6.749, p<0.001) during the liraglutide treatment. Worsening of depression and anxiety occurred in one patient but improved after the adjustment of psychiatric medications. Conclusion The current study found that liraglutide treatment in patients with a psychiatric disorder can be a safe and effective intervention for weight reduction.

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키워드

리라글루타이드 비만 체중 효과 안전성 Liraglutide Obesity Weight Effectiveness Safety